Roma have dropped into 8th place following their 2-0 defeat in Bologna last weekend.
On the other hand, Napoli are 5th after a deserved 2-1 win against Cagliari on Saturday, with Victor Osimhen bagging a goal and one of the best assists in Europe this season.
Both sides need to win due to the high competition for a Top Four finish, but their tactical and form issues might lead to a cagey game with few clear-cut chances.