Group G's standings are confirmed heading into matchday six, with these two sides set to battle it out simply for pride and confidence.
RB Leipzig missed out on the opportunity to take top spot when they threw away all three points at the Etihad two weeks ago.
BSC Young Boys, on the other hand, have secured third place and a spot in the Europa League knockout stages after their win over FK Crvena Zvezda last time out.
The home side were 3-1 victors when these sides met back in September, and a similar result should be on the cards here.