Wales must win here to be in with any chance of automatically heading to next summer's European Championship in Germany.
A win for the hosts, coupled Croatia failing to pick up all three points at home to Armenia, would send Rob Page's side through automatically.
Wales slipped up in potentially costly fashion when they travelled to Armenia on Saturday, with a 1-1 draw all they could muster up in a poor display.
The home side were beaten 2-0 when they faced Turkiye back in June, and will be aiming be on the right side of proceedings here.
Turkiye have been confirmed as winners in Group D, and fought back to secure an impressive 3-2 friendly victory away to Germany on Saturday evening.
The visitors have won three consecutive matches and should head into this one full of confidence that they can make that four.